Summary: Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance.Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.However, the composition and distribution of mutant p53 oligomers are unknown and the mechanism involved in the conversion is sparse.Here, we report accumulati
Abstract Background Tumour progression involves a series of phenotypic changes to cancer cells, each of which presents therapeutic targets.Here, using techniques adapted from microbial experimental evolution, we investigate the evolution of tumour spreading - a precursor for metastasis and tissue invasion - in environments with varied resource supp
Chemisorption processes taking place on uniformly inhomogeneous surfaces in the presence of entropic inhomogeneity are examined.A new form of linearity relationship connecting BOOK the current rate and the equilibrium constant at definite degrees of surface coverage is derived.The relationship can be applied to complex chemisorption processes when
The H1N1 pandemic of 2009 devastated Indigenous communities worldwide.In order to explain infection patterns and prevent repeating history in future pandemics, associations with infection were investigated.This revealed that the vulnerability of Indigenous communities to infection was associated with poor performance on measurements of social deter